2-Phenyl-2-propanol → 2-Phenylpropan-2-yl 2-bromoacetate

HRID 1739351Notes

Reaction equation

[C:1]1([C:7]([OH:10])([CH3:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:11][CH2:12][C:13](Cl)=[O:14]>>[Br:11][CH2:12][C:13]([O:10][C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([CH3:9])[CH3:8])=[O:14]

Participants

Reactant 2

HCID 120532-Phenyl-2-propanol

HCID 89602Bromoacetyl chloride

Product 1

HCID 538027202-Phenylpropan-2-yl 2-bromoacetate

Procedure

The sub-title compound was prepared analogously to the procedure described in Example 30(i) from 2-phenyl-2-propanol (3 g; 22 mmol) and bromacetylchloride (4.16 g, 26 mmol). Yield 1.2 g (44%).

Sources & evidence

ORD record: ord-8210d926aa414547aec79f511aca1d10
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05965692

Reaction notes

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