Thionyl Chloride → 1-(Chloromethyl)-4-(octyloxy)benzene

HRID 1739407ノート

反応式

HRID 1739407 の反応式
[CH2:1]([O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]O)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].S(Cl)([Cl:20])=O>C(Cl)(Cl)Cl>[CH2:1]([O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][Cl:20])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 144261p-Octyloxybenzyl alcohol

生成物 1

HCID 146742861-(Chloromethyl)-4-(octyloxy)benzene収率 81.6%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

2.5 g of 4-octyloxybenzyl alcohol were dissolved in 20 ml of chloroform, and the resultant solution was further fed dropwise with 1.48 g of thionyl chloride and then stirred for 1 hour at room temperature. The solution reacted was poured into ice-water and extracted with chloroform. The organic layer resulted was then dried with anhydrous magnesium sulfate, and the solvent used was removed by distillation under reduced pressure, thereby affording 2.2 g of 4-octyloxybenzyl chloride.

後処理

  1. customThe solution reacted
  2. extractionextracted with chloroform
  3. customThe organic layer resulted
  4. dry with materialwas then dried with anhydrous magnesium sulfate
  5. customthe solvent used was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-414dda7150774526a14e4f13e022a9f8
出典データセット
uspto-grants-1999_10
特許番号
US05965743

反応ノート

読み込み中…