Thionyl Chloride → HCID 15871017, compound

HRID 1739410Notes

Reaction equation

HRID 1739410 reaction equation
[C:1]1([S:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:21]=[CH:20][C:17]([CH2:18]O)=[CH:16][CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:24])=O>C(Cl)(Cl)Cl>[C:1]1([S:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:21]=[CH:20][C:17]([CH2:18][Cl:24])=[CH:16][CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 54058846HCID 54058846, compound

Product 1

HCID 15871017HCID 15871017, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1.5 g of 4-(3-benzenesulfonylpropyloxy)benzyl alcohol were dissolved in 30 ml of chloroform, and the resultant solution was further fed dropwise with 0.7 g of thionyl chloride and then stirred for 1 hour at room temperature. After completed the reaction, the solution reacted was poured into ice-water and extracted with chloroform. The organic layer resulted was dried with anhydrous magnesium sulfate, and the solvent used was removed by distillation under reduced pressure, thereby affording 1.6 g of 4-(3-benzenesulfonylpropyloxy)benzyl chloride.

Workup

  1. customthe reaction
  2. customthe solution reacted
  3. extractionextracted with chloroform
  4. customThe organic layer resulted
  5. dry with materialwas dried with anhydrous magnesium sulfate
  6. customthe solvent used was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-c034ede65a77448a8438e311086a9e89
Source dataset
uspto-grants-1999_10
Patent number
US05965743

Reaction notes

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