Dimethylformamide → 2-bromo-4-[6,7-dimethoxy-2-(4-pyridyl)methyl-phthalazin-1(2H)-on-4-yl]pyridine

Participants

Reaction Conditions

Reaction Steps

2-Bromo-4-(6,7-dimethoxyphthalazin-1(2H)-on-4-yl)pyridine (362 mg), 4-picolyl chloride hydrochloride (180 mg), and potassium carbonate (359 mg) are added to dimethylformamide (10 ml), and the mixture is heated with stirring at 80° C. for three hours under nitrogen atmosphere. Water is added to the reaction mixture, and the mixture is extracted with methylene chloride. The extract is washed, dried, and concentrated to give 2-bromo-4-[6,7-dimethoxy-2-(4-pyridyl)methylphthalazin-1(2H)-on-4-yl]pyridine (355 mg).

Provenance & Evidence