Phosphorus oxychloride → HCID 21840833, compound

Participants

Reaction Steps

To phosphorus oxychloride (100 ml) is added 3-methoxycarbonyl-4-(4-pyridyl)-6,7-dimethoxyisoquinolin-1(2H)-one (6 g), and the mixture is heated under reflux for 2.5 hours. The reaction mixture is concentrated, and thereto is added chloroform. To the mixture is further added gradually a saturated aqueous sodium hydrogen carbonate solution, and the mixture is stirred for 20 minutes. The organic layer is collected, dried, and concentrated. The residue is purified by silica gel chromatography (solvent; chloroform:ethyl acetate=5:1) to give 1-chloro-3-methoxycarbonyl-4-(4-pyridyl)-6,7-dimethoxyisoquinoline (5.17 g).

Provenance & Evidence