Acetone → HCID 4767940, compound

HRID 1739438Notes

Reaction equation

HRID 1739438 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH3:20])[CH:7]=[C:8]1[C:12](=[O:13])[O:11][C:10]([CH3:14])=[N:9]1)[CH3:2].CC(C)=[O:23]>O>[C:10]([NH:9][C:8]([C:12]([OH:11])=[O:13])=[CH:7][C:6]1[CH:15]=[CH:16][C:17]([O:18][CH2:19][CH3:20])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=1)(=[O:23])[CH3:14]

Participants

4

Reactant 2

HCID 180AcetoneHCID 544335354-[(3,4-Diethoxyphenyl)methylene]-2-methyl-5(4H)-oxazolone

Product 1

HCID 4767940HCID 4767940, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-(3,4-Diethoxybenzylidene)-2-methyloxazol-5(4H)-one (100 g) is added to acetone (200 ml) and water (400 ml), and the mixture is heated under reflux for 3.5 hours. The mixture is evaporated to remove the acetone, and cooled to room temperature. The precipitates are collected by filtration, and washed with water to give N-acetyl-3-(3,4-diethoxyphenyl)dehydroalanine (99 g).

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3.5 hours
  3. customThe mixture is evaporated
  4. customto remove the acetone
  5. filtrationThe precipitates are collected by filtration
  6. washwashed with water

Sources & evidence

ORD record
ord-5615a2e4b2724b97a9916a30136e8462
Source dataset
uspto-grants-1999_10
Patent number
US05965730

Reaction notes

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