HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl (2R,3S)-3-azido-2-hydroxy-3-phenylpropanoate → (2R,3S)-3-Phenylisoserine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl (2R,3S)-3-azido-2-hydroxy-3-phenylpropanoate | HCID 10059351 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2R,3S)-3-Phenylisoserine methyl ester | HCID 10176516 | — |
Reaction Steps
The (2R,3S)-3-azido-2-hydroxy-3-phenylpropionic acid methyl ester (1, 0.5 g) is hydrogenated over 10% palladium on carbon (0.1 g) in ethanol at atmospheric pressure for 1 hour. The reaction is filtered and evaporated to yield the desired amine. Mp 106-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965739 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-c8b78cf64d0541bd964e330cef865d22 |
| Source note | uspto-grants-1999_10 |