2-Amino-5-ethyl-1,3,4-thiadiazole → HCID 21840882, compound

HRID 1739511Notes

Reaction equation

HRID 1739511 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:7][CH3:8])=[N:5][N:6]=1.[I:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][Br:15])=[CH:12][CH:11]=1>C(#N)C>[BrH:15].[CH2:7]([C:4]1[S:3][C:2](=[NH:1])[N:6]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([I:9])=[CH:11][CH:12]=2)[N:5]=1)[CH3:8]

Participants

4

Reactant 2

HCID 264442-Amino-5-ethyl-1,3,4-thiadiazoleHCID 9542584-Iodobenzyl bromide

Product 1

HCID 21840882HCID 21840882, compoundYield 71.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To acetonitrile (10 ml) was added 2-amino-5-ethyl-1,3,4-thiadiazole (645 mg) and 4-iodobenzyl bromide (1.49 g), followed by heating under reflux for 20 hours. After the reaction mixture was cooled, the crystals so precipitated were collected by filtration and dried, whereby 1.52 g of the title compound was obtained.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 20 hours
  3. temperatureAfter the reaction mixture was cooled
  4. customthe crystals so precipitated
  5. filtrationwere collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-be219cb06e91435aa54fc52b18dbf10a
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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