Sodium Hydroxide → HCID 21840881, compound

HRID 1739513Notes

Reaction equation

HRID 1739513 reaction equation
Br.[CH2:2]([C:4]1[S:8][C:7](=[NH:9])[N:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=2)[N:5]=1)[CH3:3].[OH-].[Na+]>C(Cl)(Cl)Cl>[CH2:2]([C:4]1[S:8][C:7](=[NH:9])[N:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=2)[N:5]=1)[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21840882HCID 21840882, compound

Product 1

HCID 21840881HCID 21840881, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In chloroform (50 ml), 5-ethyl-2-imino-3-(4-iodobenzyl)-1,3,4-thiadiazoline hydrobromide (2.89 g) was suspended. To the resulting suspension was added 0.5N sodium hydroxide (25 ml), and they were stirred for 30 minutes. After separation, the organic layer was dried over anhydrous magnesium sulfate. The oily substance so obtained was crystallized from diisopropyl ether, whereby 1.85 g of the title compound was obtained.

Workup

  1. customAfter separation
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. customThe oily substance so obtained
  4. customwas crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-6ca5dad954564a87855c85009a8825ee
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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