Potassium Hydroxide → HCID 178437928, compound

HRID 1739520Notes

Reaction equation

HRID 1739520 reaction equation
[CH2:1]([C:3]1[S:7][C:6](=[N:8][C:9]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:16]([OH:18])=[O:17])=[O:10])[N:5]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[N:4]=1)[CH3:2].[OH-].[K+:38]>C(O)C>[K+:38].[K+:38].[CH2:1]([C:3]1[S:7][C:6](=[N:8][C:9]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:16]([O-:18])=[O:17])=[O:10])[N:5]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:33][N:34]=[N:35][N:36]=3)=[CH:24][CH:25]=2)[N:4]=1)[CH3:2].[CH2:1]([C:3]1[S:7][C:6](=[N:8][C:9]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:16]([O-:18])=[O:17])=[O:10])[N:5]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:33][N:34]=[N:35][N:36]=3)=[CH:24][CH:25]=2)[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178437927HCID 178437927, compound

Product 1

HCID 178437928HCID 178437928, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To 2-[[5-ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazolin-2-yliden]aminocarbonyl]-1-cyclopentenecarboxylic acid (10 g) were added 0.1N potassium hydroxide in ethanol solution (400 ml) and ethanol (600 ml) to dissolve the former in the latter. The resulting solution was concentrated to about 200 ml in total. The crystals so precipitated were collected by filtration, washed with ethanol and then dried, whereby 11 g of the title compound was obtained.

Workup

  1. dissolutionto dissolve the former in the latter
  2. concentrationThe resulting solution was concentrated to about 200 ml in total
  3. customThe crystals so precipitated
  4. filtrationwere collected by filtration
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-cf3d5d1738134db6866fb41a54946c06
Source dataset
uspto-grants-1999_10
Patent number
US05965738

Reaction notes

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