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Acetanilide → Aniline, 2,4-difluoro-6-nitro-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetanilide | HCID 904 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 2,4-Difluoroaniline | HCID 9709 | — |
| 反応物 | Sulfuric acid, mixt. with nitric acid | HCID 71777668 | — |
| 生成物 | Aniline, 2,4-difluoro-6-nitro- | HCID 9697 | — |
反応手順
Thus WO 96/02493, starting from 2,4-difluoroaniline, discloses a synthesis proceeding via five stages. 2,4-Difluoroaniline is first reacted with acetic anhydride, the resulting acetanilide is nitrated by means of HNO3 /H2SO4, the acetyl radical is removed and 2,4-difluoro-6-nitroaniline is obtained. By reaction of the 2,4-difluoro-6-nitroaniline with sodium nitrite, the amino group can be removed and 3,5-difluoronitrobenzene is obtained, which can be converted into 3,5-difluoroaniline by reduction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05965775 |
| 出典データセット | uspto-grants-1999_10 |
| ORD ID | ord-a381ac1090724e748c12032d0170d0cc |
| 出典メモ | uspto-grants-1999_10 |