3,5-Difluoroaniline → 1-Chloro-2,4,6-trifluorobenzene
Reaction equation
FC1C=C(C=C(F)C=1)N.[Cl:10][C:11]1[C:12]([F:25])=[C:13](C(O)=O)[C:14]([F:21])=[C:15]([C:19]=1[F:20])C(O)=O>>[Cl:10][C:11]1[C:12]([F:25])=[CH:13][C:14]([F:21])=[CH:15][C:19]=1[F:20]Participants
3
Procedure
EP 460 639 describes a three-stage preparation of 3,5-difluoroaniline. Starting from 5-chloro-2,4,6-trifluoroisophthalic acid, this is decarboxylated to give 2-chloro-1,3,5-trifluorobenzene. By reaction of the 2-chloro-1,3,5-trifluorobenzene with copper and water at 300° C., 1,3,5-trifluorobenzene can be prepared. According to Example 6 of EP 460 639, 1,3,5-tri-fluorobenzene is reacted with methanol saturated with ammonia at 200° C. for 60 hours and 3,5-difluoroaniline is obtained.
Sources & evidence
- ORD record
- ord-79747ed5b47b4ddead0c75f551cd8466
- Source dataset
- uspto-grants-1999_10
- Patent number
- US05965775
Reaction notes
Loading…