참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Iodophenol | HCID 10894 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Bromo-N,N-diisopropylacetamide | HCID 10900191 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N,N-bis-(isopropyl)-2-(4-iodophenoxy)-acetamide | HCID 21841486 | 108.9% |
반응 단계
1.38 g of 50% sodium hydride suspended in oil were added under an inert gas atmosphere to a solution of 5.2 g of paraiodophenol in 30 ml of tetrahydrofuran and after stirring at 0° C., then 6.30 g of N,N-bis-(isopropyl)-2-bromo-acetamide (Preparation 8) were added. After stirring for 2 hours while allowing the temperature to rise to 20° C., the reaction medium was poured into ice-cooled water and filtration was carried out followed by drying to obtain 9.3 g of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05965763 |
|---|
| 출처 데이터셋 | uspto-grants-1999_10 |
|---|
| ORD ID | ord-f4a8125f5726489482b16d92d249e459 |
|---|
| 출처 메모 | uspto-grants-1999_10 |
|---|
