2-Bromoacetamide → HCID 21841488, compound

HRID 1739567Notes

Reaction equation

HRID 1739567 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1.Br[CH2:20][C:21]([NH2:23])=[O:22]>ClCCl.CO.C(O)(=O)C>[CH:2]([N:23]([CH:5]([CH3:6])[CH3:4])[C:21](=[O:22])[CH2:20][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:3]2[C:2]([F:1])=[CH:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][C:4]=2[F:11])=[CH:13][CH:14]=1)([CH3:7])[CH3:3]

Participants

4

Reactant 2

HCID 696322-BromoacetamideHCID 21841487HCID 21841487, compound

Product 1

HCID 21841488HCID 21841488, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 21877243DCM MeOH AcOHSolvent

Procedure

An alkylation was carried out with 370 mg of the product of Stage D with 428 mg of bromoacetamide (Preparation 9) under the conditions as described in Example 13, Stage D to obtain 282 mg of the expected product with a Rf=0.35 dichloromethane/methanol/ acetic acid 95/4/1).

Sources & evidence

ORD record
ord-3f209d1199714e498062f17c779d27e4
Source dataset
uspto-grants-1999_10
Patent number
US05965763

Reaction notes

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