Methanol → HCID 54169572, compound

Participants

Reaction Steps

To a solution of 4-[1-(benzhydryl-carbamoyl)-5-(cyclopentyloxycarbonyl)amino-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid methylester (0.58 grams, 0.92 mmol) in 2:2:1 ratio of tetrahydrofuran:methanol:water (30 mL) was added lithium hydroxide monohydrate (0.19 grams, 4.50 mmol). The resulting solution was stirred at room temperature for 12 hours and then concentrated in vacuo. The crude product was treated with 1 M hydrochloric acid (aq), and the resulting precipitate collected via filtration to give 4-[1-(benzhydryl-carbamoyl)-5-(cyclopentyloxycarbonyl)amino-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid (0.514 grams, 91% yield).

Provenance & Evidence