Hydrochloric Acid → HCID 178443281, compound

Participants

Reaction Steps

L-arginine (17.4 g, 0.1 mmols) was dissolved in 100 ml of water in a three-necked round flask, and 100 ml of i-propanol were added thereto. Dodecyl glycidyl ether (48.4 g, 0.2 mols) was added thereto dropwise over a period of 30 minutes while being heat-stirred under reflux, and the mixture was stirred as such under reflux for 3 hours. After it was identified through TLC and gas chromatography that dodecyl glycidyl ether disappeared, the residue was neutralized with 10.1 g (0.1 mols) of 36-% hydrochloric acid. The reaction solution was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography (Kieselgel 60, eluent--mixture of chloroform, methanol and acetic acid at a ratio of 3:1:0.5) to give 11.4 g of N,N-bis (2-hydroxy-3-dodecyloxypropyl)-L-arginine hydrochloride in a yield of 17.2%.

Provenance & Evidence