Bromine → HCID 178517592, compound

Participants

Reaction Steps

3-Trifluoromethyl-2-pyridinol (5.0 g, 0.031 mol) was dissolved with stirring in methanol (75 mL) and bromine (5.25 g, 0.033 mol) was added dropwise with cooling. The mixture was stirred overnight and evaporated to dryness. The residue was dissolved in ethyl acetate (250 mL), washed twice with water and brine, dried over sodium sulphate and evaporated to dryness. Chromatography over silica (20% ethyl acetate:80% hexane) gave 3-trifluoromethyl-5-bromo-2-pyridinol (5.2 g) as a cream solid. M.P. 160-162° C.

Provenance & Evidence