HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl vinyl ether → 4-Bromo-3-chloro-3,4,4-trifluorobutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl vinyl ether | HCID 8023 | — |
| Reactant | 1,2-Dibromo-1-chloro-1,2,2-trifluoroethane | HCID 9634 | — |
| Reactant | 4-Bromo-3-chloro-3,4,4-trifluorobutanal | HCID 21836480 | — |
| Reactant | Sodium chlorite hydrogen peroxide | HCID 86632281 | — |
| Reactant | Sodium hydrosulfite sodium bicarbonate | HCID 86749472 | — |
| Product | 4-Bromo-3-chloro-3,4,4-trifluorobutanoic acid | HCID 10912127 | — |
Reaction Steps
A one pot reaction of 1-chloro-1,2-dibromotrifluoroethane (VI) with ethyl vinyl ether in the presence of sodium hydrosulfite/sodium bicarbonate followed by oxidation of the intermediate, 4-bromo-3 chloro-3,4,4-trifluorobutanal (VII), without isolation, with sodium chlorite/hydrogen peroxide to give 4-bromo-3-chloro-3,4,4-trifluorobutanoic acid (VIII) in overall unexpected yields;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05968916 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-9309ab68a11340098fe48972e78f2505 |
| Source note | uspto-grants-1999_10 |