Tetrahydrofuran → HCID 21837264, compound

Participants

Reaction Steps

1.25 ml of N-methyl piperazine is added to a solution containing 2.53 g of 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-8-methyl-4-[[(trifluoromethyl)sulphony]oxy]-2H-1-benzopyran-2-one and 22 ml of THF. The reaction medium is maintained under agitation for 1 hour, poured into a 1M aqueous solution of sodium acid phosphate, and extraction is carried out with ethyl acetate. The organic phases are combined, washed, dried and concentrated under reduced pressure. Chromatography is carried out on silica eluting with a methanol-methylene chloride mixture (6-94). 2.31 g of sought product is isolated. rf=0.3.

Provenance & Evidence