Chloroform → HCID 86754621, compound

Participants

Reaction Steps

The reaction was conducted as described in Example 3, using 0.1 g (0.28 mmol) di (±)-trans-7-benzylidene-1,2,3,4,4a,5,6,7,8,8a-decahydro-2-methyl-4a-(3-methoxyphenyl)-6-isoquinolinone, 0.16 ml (1.7 mmol) of boron tribromide and 6 ml of dry CHCl3. The crude reaction mixture was purified by flash chromatography, eluting with a mixture CH2Cl2 /MeOH/conc. NH4OH 86:10:0.6 respectively. The resulting solid was dissolved in MeOH and the solution brought to acidic pH with Et2O/HCl. The solvent was removed in vacuo, the resulting solid was triturated with acetone, yielding 0.07 g of the title compound. M.p.=256-260° C.

Provenance & Evidence