反应详情

The reaction was conducted as described in Example 10, using 0.77 g (2.2 mmol) of (±)-trans-2-ethyl-4a-(3-methoxyphenyl)-6-phenyl-1 ,2,3,4,4a,5,8,8a-octahydroisoquinoline, 1.32 g (8.8 mmol) of NaI, 1.1 ml (8.8 mmol) of chlorotrimethylsilane and 20 ml of acetonitrile. The crude reaction mixture was purified by flash chromatography, eluting with a mixture CH2Cl2 /MeOH/conc. NH4OH 90:7:0.7 respectively. The resulting solid was triturated in acetone, yielding 0.115 g of the title compound. M.p.=215-218° C. C23H27NO

1. customThe crude reaction mixture
2. customwas purified by flash chromatography
3. washeluting with a mixture CH2Cl2 /MeOH/conc
4. customThe resulting solid was triturated in acetone