反应详情

The reaction was conducted as described in Example 10, using 0.93 g (2.6 mmol) of (±)-trans-6-benzylidene-1,2,3,4,4a,5,6,7,8,8a-decahydro-2-ethyl4a-(3-methoxyphenyl)isoquinoline, 1.54 g (10.3 mmol) of NaI, 1.3 ml (10.3 mmol) of chlorotrimethylsilane and 20 ml of acetonitrile. The crude reaction mixture was purified by flash chromatography, eluting with a mixture CH2Cl2 /MeOH/conc. NH4OH 90:7:0.7 respectively. The resulting solid was crystallised from Et2O, yielding 0.09 g of the title compound. M.p.=160-162° C.

1. customThe crude reaction mixture
2. customwas purified by flash chromatography
3. washeluting with a mixture CH2Cl2 /MeOH/conc
4. customThe resulting solid was crystallised from Et2O