Sulfuric Acid → HCID 21837530, compound

Participants

Reaction Steps

1.03 g (4.1 mmol) of the product of Step 1 are dissolved in 4 ml of acetonitrile. 1 ml of concentrated H2SO4 is added dropwise over a period of 5 minutes while the temperature is maintained below 40° C. The whole is stirred overnight at room temperature and then poured into 50 ml of ice-cold 1N sodium hydroxide solution. The whole is extracted with methylene chloride, washed with water, dried and evaporated to yield 0.85 g of residue, which is purified by flash chromatography (eluants:methylene chloride/ethyl acetate: 50/50, then methylene chloride/methanol: 98/2). 0.54 g of the expected product is obtained.

Provenance & Evidence