反应详情

温度

0 °C

1.62 g of KNO3 is introduced in portions into 2.85 g (15 mmol) of 2-acetylamino-5-aminoindan in 7.5 ml of concentrated H2SO4 that has been cooled to 0° C. The whole is stirred for 3 hours at 0° C. and then poured into ice-cold 6N sodium hydroxide solution, stirred, extracted with methylene chloride and then washed, dried and evaporated. 2.8 g of a black solid are isolated, which is purified on silica (eluant:methylene chloride/methanol: 97/3). In that manner, 1.46 g of the expected product are isolated. Yield: 42%.

1. stirringstirred
2. extractionextracted with methylene chloride
3. washwashed
4. customdried
5. customevaporated