Pyridine → HCID 15839988, compound

Participants

Reaction Conditions

Reaction Steps

1.1 g (6.5 mmol) of 8-chloro-2,3-dihydro-1,4-dioxino[2,3-b]pyridine, 3 g (13 mmol) of 4[N-(indan-2-yl)-N-methylamino]piperidine and 5 ml of pyridine are placed in a reactor. The whole is heated at 130° C. for 8 hours. After cooling, the whole is taken up in toluene and concentrated. The residue is chromatographed on 130 g of silica (eluant: CH2Cl2 /CH3OH/NH4OH, 95/5/0.5) to yield the expected product which melts (MK) at 167-170° C. Yield=8.5%.

Provenance & Evidence