反应详情

Imidazole (121.8 g) was added to a mixture of 1-(chlorophenylmethyl)-4-nitrobenzene (88.7 g) in ACN (1000 ml) and the reaction mixture was stirred and refluxed for 24 hours. The solvent was evaporated. The residue was dissolved in toluene, washed with a 10% K2CO3 solution, dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 98/2). The pure fractions were collected and the solvent was evaporated, yielding 53 g (53%) of 1-[(4-nitrophenyl)phenylmethyl]-1H-imidazole (interm. 1-a).

1. temperaturerefluxed for 24 hours
2. customThe solvent was evaporated
3. dissolutionThe residue was dissolved in toluene
4. washwashed with a 10% K2CO3 solution
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customevaporated
8. customThe residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 98/2)
9. customThe pure fractions were collected
10. customthe solvent was evaporated