反应详情

Interm. (7-a) (50 g) and then (3-chlorophenyl)acetonitrile (34.8 ml) were added to a mixture of sodium hydroxide (32.8 g) in methanol (100 ml). The mixture was stirred and refluxed till complete dissolution. The reaction was carried out twice with the same quantities. The mixtures were combined. Ice and then ethanol were added. The mixture was allowed to crystallize out. The precipitate was filtered off, washed with ethanol and dried, yielding 58 g (86%) of 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole (interm. 9-a).

1. temperaturerefluxed till complete dissolution
2. customto crystallize out
3. filtrationThe precipitate was filtered off
4. washwashed with ethanol
5. customdried