Ammonium Chloride → HCID 21837610, compound

Participants

Reaction Steps

A mixture of 6-(4-ethyl-2-thiazolylthio)-5-nitro-3H-isobenzofuran-1-one (750 mg, 2.33 mmol), Fe powder (600 mg, 10.7 mmol) and NH4Cl (150 mg, 2.8 mmol) in 45 mL of EtOH:H2O (2:1) was refluxed for 1.5 h. The hot mixture was filtered through celite and the celite was washed several times with hot EtOH:THF (4:1). Solvent was evaporated in vacuo and the residue was partitioned between H2O and EtOAc. The organic layer was separated, washed with brine, dried over MgSO4 and concentrated. The solid title compound so obtained was used without purification in the next step.

Provenance & Evidence