Dimethylformamide → 1-(2-nitrophenyl)-1H-pyrrole-2-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.76 g of 1-(2-nitrophenyl)pyrrole in 20 ml of N,N-dimethylformamide at 0° C. is added dropwise with stirring 3 ml of phosphorus oxychloride. Stirring is continued for 30 minutes and the reaction mixture is heated at 90° C. for 1 hour. After cooling to room temperature the mixture is treated with crushed ice and the pH adjusted to 12 with 2N sodium hydroxide. The resulting suspension is filtered, washed-with water and dried to give 5.81 g of the desired product as a light yellow solid m.p. 119°-122° C.

Provenance & Evidence