Ethanol → 4-[(5-Fluoro-2-methylbenzoyl)amino]benzoic acid

Participants

Reaction Steps

A mixture of 0.60 g of ethyl 4-[(5-fluoro-2-methylbenzoyl)amino]benzoate 0.60 ml of 10 N NaOH, 25 ml of water and 50 ml of absolute ethyl alcohol is heated on a steam bath for 1 hour, cooled and acidified with acetic acid. The resulting solid is filtered and dried in vacuo at 60-80° C. to give 0.47 g of the desired product as a solid, m.p. 272-275° C.

Provenance & Evidence