Hydrochloric Acid → HCID 15406907, compound

Participants

Reaction Steps

5.5 g of cyclohexyltriphenylphosphonium bromide and 2.6 g of KOtBu were stirred at RT for 4 h in 200 ml of anhydrous THF. 3.0 g of 4'-formylbiphenyl-2-sulfonamide were added and the mixture was stirred at RT for 18 h. It was then diluted with 200 ml of EA, adjusted to pH=6-7 using aqueous HCl solution and washed 2 times with 100 ml of a saturated aqueous NaCl solution each time. The organic phase was dried over Na2SO4 and the solvent was removed in vacuo. Chromatography on silica gel using DIP yielded 1.5 g of a colorless oil.

Provenance & Evidence