HRID1740213

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C

HCID10474604

3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

C20H29N3O4

HCID21836594

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Oc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NC(=O)OC(C)(C)C)CCc3ccccc32)cc1

HCID22877467

未命名化合物

PROCEDURE

实验过程

Prepared from 4-bromomethyl-2'-acetoxy-1,1'-biphenyl and 3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide (Example 1, Step I) by the procedure described in Example 1, Step Q. 1H NMR (200 MHz, CDCl3): δ 1.38 (s, 6H), 1.45 (s, 9H), 1.85 (m, 1H), 2.02 (s, 3H), 2.35-2.65 (m, 5H), 4.52 (m, 1H), 4.84 (d, 15 Hz, 1H), 5.30 (d, 15 Hz, 1H), 6.71 (d, 7 Hz, 1H), 7.1-7.4 (m, 12H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dda7d1f18365401b84e1deee851c74a3
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05968924
来源说明: uspto-grants-1999_10

反应 SMILES

Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1.[C:19]([O:23][C:24]([NH:26][C:27]([CH3:45])([CH3:44])[CH2:28][C:29]([NH:31][C@@H:32]1[CH2:38][CH2:37][C:36]2[CH:39]=[CH:40][CH:41]=[CH:42][C:35]=2[NH:34][C:33]1=[O:43])=[O:30])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:16]([O:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:6]1[CH:7]=[CH:8][C:3]([CH2:2][N:34]2[C:35]3[CH:42]=[CH:41][CH:40]=[CH:39][C:36]=3[CH2:37][CH2:38][C@@H:32]([NH:31][C:29](=[O:30])[CH2:28][C:27]([NH:26][C:24]([O:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:25])([CH3:45])[CH3:44])[C:33]2=[O:43])=[CH:4][CH:5]=1)(=[O:18])[CH3:17]