HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | (R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one | HCID 10103689 | — |
| Reactant | 3-(((Benzyloxy)carbonyl)amino)-3-methylbutanoic acid | HCID 14551007 | — |
| Product | 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide | HCID 10573563 | — |
Reaction Steps
Prepared from 3-benzyloxycarbonylamino-3-methylbutanoic acid (Step C) and 3(R)-amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one (Example 1, Step E) substituting benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate for benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate according to the procedure described in Example 1, Step I. 1H NMR (200 MHz, CDCl3): δ 1.37 (s, 6H), 1.82 (m, 1H), 2.45-2.75 (m, 4H), 2.86 (m, 1H), 4.49 (m, 1H), 5.05 (dd; 10, 6 Hz; 2H), 5.55 (s, 1H), 6.73 (s, 1H), 6.96 (d, 4 Hz, 1H), 7.10-7.40 (m, 8H) and 8.68 (s, 1H). FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05968924 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-ec19d6416c3d4608990a9058c60dc788 |
| Source note | uspto-grants-1999_10 |