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HRID1740240

反应详情

EQUATION

反应方程式

HRID 1740240 的结构方程式

REACTANTS

反应物

2
结构：CNC(=O)NCc1ccccc1-c1ccc(CO)cc1
HCID11173273

未命名化合物

结构：CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC[C@H]1COC(C)(C)O1
HCID22877454

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NC[C@H]3COC(C)(C)O3)CCc3ccccc32)cc1
HCID22877453

未命名化合物

PROCEDURE

实验过程

Prepared from 3-[[2,2-dimethyl-1,3-dioxolan-4(S)-yl]-methyl]amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide (Step B) and 2'-[[(methylamino)carbonyl]amino]methyl-1,1'-biphenyl-4-methanol, methanesulfonate ester (Example 48, Step I) according to the procedure described in Example 35, Step H.1H NMR (200 MHz, CD3OD): δ 1.14 (s, 6H), 1.28 (s, 3H), 1.34 (s, 3H), 2.07 (m, 1H), 2.20-2.42 (m, 3H), 2.48-2.76 (m, 4H), 2.64 (s, 3H), 3.64 dd; 8, 6 Hz; 1H), 4.05 (dd; 8, 6 Hz; 1H), 4.14 (s, 2H), 4.20 (m, 1H), 4.40 (dd; 12, 8 Hz; 1H), 4.94 (d, 15 Hz, 1H), 5.27 (d, 15 Hz, 1H), 7.10-7.40 (m, 12H). FAB-MS: calculated for C37H46N5O5 641; found 642 (M+H, 80%).