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HRID1740249

反应详情

EQUATION

反应方程式

HRID 1740249 的结构方程式

REACTANTS

反应物

3
结构：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F
HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

结构：CC(C)(C)OC(=O)NC(C)(C)C(=O)O
HCID2733845

N-((1,1-Dimethylethoxy)carbonyl)-2-methyl-alanine

C9H17NO4

结构：N[C@@H]1CCc2ccccc2NC1=O
HCID10103689

(3R)-3-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

C10H12N2O

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@@H]1CCc2ccccc2NC1=O
HCID10808566

未命名化合物

PROCEDURE

实验过程

Prepared from N-t-butoxycarbonyl-2-methylalanine and 3(R)-amino-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (Example 1, Step E) substituting benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate for benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate according to the procedure described in Example 1, Step I. 1H NMR (200 MHz, CDCl3): δ 1.47 (s, 3H), 1.52 (s, 3H), 1.82 (m, 1H), 2.50-3.00 (m, 3H), 4.45 (m, 1H), 5.05 (s, 2H), 5.37 (s, 1H), 6.80-7.40 (m, 10H) and 8.65 (s, 1H). FAB-MS: calculated for C22H25N3O4 395; found 396 (M+H, 100%).