2'-[(t-Butoxycarbonylamino)methyl]-1,1-biphenyl-4-methanol → HCID 22877442, compound

HRID 1740256Notes

Reaction equation

HRID 1740256 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[C:13]([NH:15][C@@H:16]1[CH2:22][CH2:21][C:20]2[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:19]=2[NH:18][C:17]1=[O:28])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]([O:35][C:36]([NH:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1[C:46]1[CH:51]=[CH:50][C:49]([CH2:52]O)=[CH:48][CH:47]=1)=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[C:13]([NH:15][C@@H:16]1[CH2:22][CH2:21][C:20]2[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:19]=2[N:18]([CH2:52][C:49]2[CH:48]=[CH:47][C:46]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][C:40]=3[CH2:39][NH:38][C:36]([O:35][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:37])=[CH:51][CH:50]=2)[C:17]1=[O:28])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 220084722'-[(t-Butoxycarbonylamino)methyl]-1,1-biphenyl-4-methanolHCID 22877443HCID 22877443, compound

Product 1

HCID 22877442HCID 22877442, compound

Procedure

Prepared from 2-benzyloxycarbonylamino-2-methyl-N-[7-fluoro-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]propanamide (Step E) and 2'-[(t-butoxycarbonylamino)methyl]-1,1'-biphenyl-4-methanol, methanesulfonate ester (Example 35, Step G) according to the procedure described in Example 35, Step H. 1H NMR (200 MHz, CDCl3): δ 1.39 (s, 9H), 1.48 (s, 3H), 1.51 (s, 3H), 1.78 (m, 1H), 2.35-2.70 (m, 3H), 4.18 (d, 7 Hz, 2H), 4.42 (m, 1H), 4.58 (m, 1H), 4.75 (d, 16 Hz, 1H), 5.05 (s, 2H), 5.27 (d, 16 Hz, 1H), 5.35 (s, 1H), 6.88 (dd; 8, 6 Hz; 1H), 6.98 (m, 1H), 7.09 (d, 6 Hz,1 H), 7.14-7.35 (m, 13H), 7.40 (d, 8HZ, 1H). FAB-MS: calculated for C41H45FN4O6 708; found 709 (M+H).

Sources & evidence

ORD record
ord-28f9808c480b4c37a18b6b72355eda0e
Source dataset
uspto-grants-1999_10
Patent number
US05968924

Reaction notes

Loading…