Dichloroacetic Acid → HCID 21837909, compound

HRID 1740275Notes

Reaction equation

HRID 1740275 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[C:18]([CH:19]([CH3:21])[CH3:20])=[CH:17][CH:16]=[CH:15][C:14]=1[CH:22]([CH3:24])[CH3:23].[Cl:25][CH:26]([Cl:30])[C:27]([OH:29])=[O:28]>C(OCC)(=O)C.CCCCCCC>[Cl:25][C:26]([Cl:30])([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[C:18]([CH:19]([CH3:21])[CH3:20])=[CH:17][CH:16]=[CH:15][C:14]=1[CH:22]([CH3:24])[CH3:23])[C:27]([OH:29])=[O:28]

Participants

4

Reactant 2

HCID 6597Dichloroacetic AcidHCID 21837947HCID 21837947, compound

Product 1

HCID 21837909HCID 21837909, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

7.95 g (20.0 mmol) 81 was reacted with 10.3 g (80.0 mmol) dichloroacetic acid as in example 9. Flash chromatography (ethyl acetate/heptane 1:10) yielded 4.7 g (53%) 29 as a light coloured oil.

Sources & evidence

ORD record
ord-69aa4f194b524b2ebcf1143c26890a0e
Source dataset
uspto-grants-1999_10
Patent number
US05968982

Reaction notes

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