Sulfuric Acid → HCID 21837917, compound

HRID 1740277Notes

Reaction equation

HRID 1740277 reaction equation
[Cl:1][C:2]([Cl:18])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[C:3]([OH:5])=[O:4].S(=O)(=O)(O)[OH:20]>>[C:16]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:2]([Cl:18])([Cl:1])[C:3]([OH:5])=[O:4])(=[O:20])[NH2:17]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 15338405HCID 15338405, compound

Product 1

HCID 21837917HCID 21837917, compound

Procedure

200 mg (0.70 mmol) 8 was fed into 10 ml 80% sulfuric acid and kept at room temperature for 6 h. The solution that was obtained was poured into 150 ml ice water, the beige-coloured precipitate was suction filtered and washed with petroleum ether. 180 mg (85%) 35, melting point 93-94° C.

Workup

  1. customThe solution that was obtained
  2. filtrationfiltered
  3. washwashed with petroleum ether

Sources & evidence

ORD record
ord-22edcc066ab24c09878f4df0f1f585f2
Source dataset
uspto-grants-1999_10
Patent number
US05968982

Reaction notes

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