Dichloroacetic Acid → HCID 21837958, compound

HRID 1740278Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1.[Cl:21][CH:22]([Cl:26])[C:23]([OH:25])=[O:24]>>[Cl:21][C:22]([Cl:26])([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)[C:23]([OH:25])=[O:24]

Participants

Reactant 2

HCID 6597Dichloroacetic Acid

HCID 21837930HCID 21837930, compound

Product 1

HCID 21837958HCID 21837958, compoundYield 45%

Procedure

3.90 g (11.1 mmol) 1-bromo-12-(4-chlorophenyl)-dodec-6-yne 89 was reacted with 11.4 g (89 mmol) dichloro-acetic acid analogously to example 9. 2.00 g (45%) 38 was obtained as a colourless oil.

Sources & evidence

ORD record: ord-e870dcbd3c28486fb39ef472b5924e4f
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05968982

Reaction notes

Loading…