(+-)-Methionine → HCID 21838360, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 3-(3,5-dimethoxyphenyl)benzoate (0.83 g) and d,l-methionine (9.10 g) in methanesulfonic acid (19.8 ml) was stirred at 40° C. for 10 hours. The mixture was poured onto ice-water and then the product was extracted with ethyl acetate and washed with sodium hydrogencarbonate solution and brine. The organic layer was dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture of chloroform and acetone (5:1). The fractions containing the desired product was collected and evaporated in vacuo to give methyl 3-(3,5-dihydroxyphenyl)benzoate.

Provenance & Evidence