反应详情

A mixture of 2-[3-(benzofuran-4-yl)phenyl]-4,4-dimethyl-4,5-dihydrooxazole (1.4 g), concentrated sulfuric acid (0.8 ml) and water (1 ml) in methanol (20 ml) was refluxed for 48 hours. After evaporating the solvent, the residue was dissolved in a mixture of ethyl acetate (50 ml) and water (50 ml). The organic layer was successively washed with 10% sodium carbonate aqueous solution, brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was purified by column chromatography on silica gel eluting with toluene. The fractions containing the desired products were collected and evaporated in vacuo to afford methyl 3-(benzofuran-4-yl)benzoate (0.77 g).

1. temperaturewas refluxed for 48 hours
2. customAfter evaporating the solvent
3. dissolutionthe residue was dissolved in a mixture of ethyl acetate (50 ml) and water (50 ml)
4. washThe organic layer was successively washed with 10% sodium carbonate aqueous solution, brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was evaporated in vacuo
7. customthe residue was purified by column chromatography on silica gel eluting with toluene
8. additionThe fractions containing the desired products
9. customwere collected
10. customevaporated in vacuo