HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1740307Generated: October 31, 2026
Hydrochloric Acid → methyl 5-[(E)-2-carboxyethenyl]-3-iodobenzoate
https://huagongshe.com/reaction/1740307
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Methyl 3-formyl-5-iodobenzoate | HCID 21838328 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | methyl 5-[(E)-2-carboxyethenyl]-3-iodobenzoate | HCID 21838304 | 83.8% |
Reaction Steps
The mixture of methyl 5-formyl-3-iodobenzoate (2.5 g), malonic acid (1.8 g) and piperidine (0.2 ml) in pyridine (25 ml) was stirred for 3 hours at 100° C. The mixture was added to water and adjusted to pH 2 with 6N-hydrochloric acid. The isolated precipitate was collected by filtration to give methyl 5-[(E)-2-carboxyethenyl]-3-iodobenzoate (2.4 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05968985 |
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| Source dataset | uspto-grants-1999_10 |
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| ORD ID | ord-b0477cdb665e44c5bcb83e40fb36b959 |
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| Source note | uspto-grants-1999_10 |
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