N,N-Dimethylethylenediamine → HCID 21837985, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of dimethyl 5-hydroxyisophthalate (2 g) and N,N-dimethylethylenediamine (1.04 ml) was heated at 100° C. for 2 hours. After being cooled to room temperature, the reaction mixture was evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture of chloform, methanol and triethylamine (100:10:1) to give methyl 3-[(2-dimethylaminoethyl)carbamoyl]-5-hydroxybenzoate (1.11 g).

Provenance & Evidence