反应详情

温度

65 °C

Into a 1000 mL, round-bottomed flask equipped with air condensers and a magnetic stirring plate was charged N,N-dimethyldodecylamine (308.8 grams, 1.45 moles), 1-bromo-4-chlorobutane (249.98 grams, 1.45 moles) and 300 mL of methanol. The reaction was maintained at 65° C. for 48 hours. Solvent was removed by rotary evaporation under reduced pressure to yield brown oil. To the oil was added 100 ml of 1-butanol. The mixture was distilled under vacuum at 30° C. to 50° C. until distillate stopped collecting. Yield 384.47 grams (0.99 moles, 69%).

1. customInto a 1000 mL, round-bottomed flask equipped with air condensers
2. customSolvent was removed by rotary evaporation under reduced pressure
3. customto yield brown oil
4. distillationThe mixture was distilled under vacuum at 30° C. to 50° C. until distillate
5. customstopped collecting