1,4-Dioxane hydrochloride → HCID 21838655, compound

HRID 1740381Notes

Reaction equation

HRID 1740381 reaction equation
C([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][O:11][CH3:12])[CH2:5][CH2:4]1)=O.[ClH:13].O1CCOCC1>CO>[ClH:13].[ClH:13].[CH3:12][O:11][CH2:10][CH2:9][N:6]1[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 218386494-(2-Methoxyethyl)piperazine-1-carbaldehyde

Product 1

HCID 21838655HCID 21838655, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 57.2 g of 1-formyl-4-methoxyethylpiperazine in 100 mL of methanol was added dropwise 180 mL of 4N-hydrochloric acid/1,4-dioxane over 1.5 hours. The mixture was stirred at room temperature for 1 hour, and the resulting crystals were filtered, washed with isopropyl ether and dried in vacuo to give 68.8 g of the title compound.

Workup

  1. filtrationthe resulting crystals were filtered
  2. washwashed with isopropyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0266294c143243be8e76115d5cdfc74c
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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