HCID 21838655, compound → 1-(2-Methoxyethyl)piperazine

HRID 1740382Notes

Reaction equation

HRID 1740382 reaction equation
Cl.Cl.[CH3:3][O:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1>[OH-].[Na+]>[CH3:3][O:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

Participants

3

Reactant 1

HCID 21838655HCID 21838655, compound

Product 1

HCID 27346381-(2-Methoxyethyl)piperazineYield 90.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To an aqueous solution of 68.8 g of 1-(2-methoxyethyl)piperazine dihydrochloride (water; 50 mL) was added dropwise an aqueous solution of 33.0 g of sodium hydroxide (water; 100 mL). The mixture was extracted with chloroform. The, organic layer was dried over anhydrous magnesium sulfate and evaporated to give 41.3 g of the title compound.

Workup

  1. extractionThe mixture was extracted with chloroform
  2. dry with materialThe, organic layer was dried over anhydrous magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-6c9a3e0f396c46da8a3a000fcda91ccb
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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