Sulfuric Acid → HCID 86754638, compound

HRID 1740403Notes

Reaction equation

HRID 1740403 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][O:27][CH3:28])[CH2:21][CH2:20]3)[C:14]2=[O:29])=[CH:9][CH:8]=1>C(O)C>[OH2:2].[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([CH2:18][N:19]3[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][O:27][CH3:28])[CH2:23][CH2:24]3)[C:14]2=[O:29])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 9892249MS-377

Product 1

HCID 86754638HCID 86754638, compoundYield 161.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 101 mg of conc. sulfuric acid in 5 mL of ethanol was added to a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethanol. The mixture was stirred at room temperature and then concentrated to 3 mL. To the mixture was added 5 mL of ethyl acetate. The precipitated solid was filtered and dried to give 389 mg of the title compound.

Workup

  1. concentrationconcentrated to 3 mL
  2. additionTo the mixture was added 5 mL of ethyl acetate
  3. filtrationThe precipitated solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-c148fb72c0144221b14b237bcd263045
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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