HCID 54085496, compound → HCID 15498792, compound

Participants

Reaction Steps

A solution of N-tert-butoxycarbonyl-O-benzyl-D-valinol (9.95 g, 34 mmol) in formic acid (50 mL) is stirred for 4 hours at room temperature. After removal of the formic acid under vacuum, the sticky residue is dissolved in water (100 mL), neutralized with a saturated solution of sodium bicarbonate (100 mL) and the organic material is extracted twice with ethyl acetate (2×200 mL). The organic phases are washed until neutral with water (2×200 mL) and the combined organic layers are dried over anhydrous sodium sulfate. Filtration and concentration under vacuum provides O-benzyl-D-valinol as a slightly yellowish oil (5.20 g, 79%).

Provenance & Evidence