Potassium Hydroxide → HCID 21838743, compound

HRID 1740491Notes

Reaction equation

HRID 1740491 reaction equation
[OH-].[K+].[CH2:3]([O:5][C:6]([NH:8][C:9]1[C:13]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:17][C:12]=2[O:11][C:10]=1[C:26]([O:28]CC)=[O:27])=[O:7])[CH3:4]>C(O)C>[CH2:3]([O:5][C:6]([NH:8][C:9]1[C:13]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:17][C:12]=2[O:11][C:10]=1[C:26]([OH:28])=[O:27])=[O:7])[CH3:4]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 21838723HCID 21838723, compound

Product 1

HCID 21838743HCID 21838743, compoundYield 104,892.703%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

200 ml of a 10% ethanolic potassium hydroxide solution are added to a solution of 41 g (0.11 mmol) of ethyl 3-[(ethoxycarbonyl)amino]-6-(phenylmethoxy)benzofuran-2-carboxylate in 400 ml of ethanol. The mixture is heated at reflux for 30 minutes and the solvent is then evaporated under reduced pressure. The residue is taken up in water and the solution is acidified with hydrochloric acid to pH 2. 41 g of product are obtained by filtration of the precipitate formed.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 30 minutes
  3. customthe solvent is then evaporated under reduced pressure

Sources & evidence

ORD record
ord-629193eb38b84ee2ac2eefbe6a5b21e4
Source dataset
uspto-grants-1999_10
Patent number
US05969146

Reaction notes

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