Ammonium Hydroxide → HCID 15381204, compound

Participants

Reaction Conditions

Reaction Steps

46 ml of a 1M solution of boron tribromide (0.046 mol) in dichloromethane are added to a solution of 7.7 g (0.031 mol) of ethyl (6-methoxybenzo[b]thien-3-yl)carbamate in 80 ml of dichloromethane, while maintaining the temperature at 0° C. The mixture is allowed to return to room temperature and 15 ml of a 1M solution of boron tribromide (0.015 mol) in dichloromethane are added. The mixture is stirred for 180 min, neutralization is then carried out with a dilute ammonium hydroxide solution and the precipitate obtained is filtered off. The latter is washed with water and dried. Purification is carried out by chromatography on a column of silica gel with dichloromethane. 6 g of product are obtained.

Provenance & Evidence